http://miranda-ng.org/
It allows you to use MSN, IRC, Facebook chat, and many other protocols all at the same time. It's really complex, but very cleverly designed. It has a lot of nice notification options and using only 2-3 MB of your RAM (if you're not installing a lot of plugins).
Sure, I'm not suggesting you this if you're an advanced IRC user who likes scripting and stuff. Those ones should stick to mirc or HydraIRC.
